Clostridium difficile Infection News

• Updated Guidance Supports FMT for CDI, But Not IBD or IBS Based on a synthesis of best available evidence, the AGA released clinical recommendations on fecal microbiota-based therapies in adults with gastrointestinal diseases.
  MDedge News, March 15, 2024
• ECCO 2024 Novel Biotherapeutic to Be Tested in Ulcerative Colitis An investigational combination of eight strains of bacteria known collectively as MB310 — a live biotherapeutic product — is due to start its first clinical trial in ulcerative colitis.
  Medscape Medical News, February 26, 2024
• Where Is the 'Microbiome Revolution' Headed Next? Famed microbiome researcher Dr Martin J. Blaser shares what he sees as the most promising applications, and the rigorous clinical trials needed to realize them.
  Medscape Medical News, December 19, 2023
• How the Microbiome Influences the Success of Cancer Therapy Microbial diversity affects whether a tumor grows, leads to inflammation, develops immune escape mechanisms, or develops therapeutic resistance, said an internal medicine specialist.
  Medscape Medical News, December 04, 2023
• Use the Stool! Fecal Transplants Help Kids With C Diff The American Academy of Pediatrics endorsed fecal transplants to eliminate a particular infection in children and called for more research about other uses.
  Medscape Medical News, November 20, 2023
• ACG 2023 IMT Improves Clinical Outcomes in IBD: Meta-Analysis Researchers found significant improvements for intestinal microbiota transplant in one type of inflammatory bowel disease but not another.
  Medscape Medical News, October 31, 2023
• What Should GPs Know About the Gut Microbiome? For one, it can be significantly impacted by diet and medication.
  Univadis, October 12, 2023
• Post SCT, Better Survival in Kids With Healthy Gut Diversity Pediatric patients receiving a donor stem cell transplant who have healthier pretransplant gut microbiota diversity show improved rates of survival and a lower risk of acute GvHD.
  MDedge News, August 25, 2023
• ILC 2023 FMT Modifies Gut Microbiome, Reduces Ammonia in Cirrhosis Fecal microbiota transplant (FMT) promotes restoration of the gut microbiota, enzymes, and immune responses, and reduces ammonia build-up in patients with cirrhosis, a pilot study found.
  Medscape Medical News, June 23, 2023
• Unraveling the Mechanisms Behind FMT Efficacy Already successful in treating C difficile, fecal microbiota transplant could be applied to noncommunicable diseases, but better understanding of donor-recipient pairing is critical.
  Medscape Medical News, June 07, 2023
• FMT in a Pill: FDA OKs Second Product to Prevent Recurrent C difficile Clinicians now have two approved options for recurrent infections after antibiotic treatment.
  Medscape Medical News, April 28, 2023
• Alert FDA Approves Treatment for Deadly C. Difficile Infections The FDA on Wednesday approved Seres Therapeutics's pill for treating a type of bacterial infection, giving an easier and standardized option to patients who often have to rely on individual donors for fecal transplants.
  Reuters Health Information, April 26, 2023
• Antibiotics in Previous Year Reduce ICI Effectiveness After finding that immune checkpoint inhibitors (ICIs) do not work as well for patients who had taken antibiotics, the investigators suggest restoring the gut microbiome before starting therapy.
  Medscape Medical News, March 07, 2023
• Real-World Study Looks at Use of Bezlotoxumab, FMT for CDI A single-center study suggests that FMT and bezlotoxumab ― two recommended therapies for recurrent C difficile infections ― are not commonly used in Spain, which doesn't appear to align with US practice.
  Medscape Medical News, February 23, 2023
• FMT Doesn't Appear to Affect Weight Loss After Bariatric Surgery Fecal microbiota transplantation did not provide additional benefit in terms of weight loss for patients who underwent bariatric surgery in a randomized placebo-controlled trial.
  Medscape Medical News, December 21, 2022
• Oral FMT on Par With Colonic FMT for Recurrent C difficile Freeze-dried, encapsulated fecal microbiota transplantation (FMT) has a safety and effectiveness profile similar to that of liquid colonic FMT, without the procedural risks of colonoscopy.
  Medscape Medical News, October 31, 2022
• ACG 2022 RBX2660 Shows Promise in Breaking the Cycle of Recurrent C diff Building on the success seen with fecal microbiota transplantation, this experimental treatment lowered the rates of recurrent C difficile infections.
  Medscape Medical News, October 27, 2022
• IDWeek 2022 C. Diff Recurrence Drops With Highly Targeted Ridinilazole Phase 3 study results show the highly specific antibiotic was safe and effective and particularly effective in patients not taking another antibiotic.
  Medscape Medical News, October 20, 2022
• UEG 2022 FMT in IBS: 'We've Been Targeting Wrong Part of the Intestine' When administered to the small, rather than the more commonly used large, intestine, fecal microbiota transplantation results in sustained and better response rates in IBS, according to a new study.
  Medscape Medical News, October 14, 2022
• FMT Plus Anti-Inflammatory Diet Induces Remission in UC: Study In this more practically applicable study, the dietary intervention could be continued for a longer period, one expert observed.
  MDedge News, October 13, 2022